Platelet Count to Spleen Diameter Ratio for the Diagnosis of Gastroesophageal Varices in Liver Cirrhosis: A Systematic Review and Meta-Analysis
نویسندگان
چکیده
Platelet count to spleen diameter ratio (PSR) was studied extensively as a noninvasive method of diagnosis for varices. The present study aimed to systematically assess the performance of PSR in the diagnosis of varices. PubMed, EMBASE, and article references were searched. The summary receiver operating characteristic curves (AUSROCs), sensitivities, specificities, positive and negative likelihood ratio, and diagnostic odds ratio were calculated. The heterogeneity, quality, and publication bias of studies were evaluated. Subgroup and sensitivity analyses were performed. A total of 49 papers were included. The AUSROCs of PSR for any varices and high-risk varices were 0.8719 and 0.8132, respectively. The summary sensitivities of PSR for any varices and high-risk varices were 0.84 and 0.78, respectively. The summary specificities of PSR for any varices and high-risk varices were 0.78 and 0.67, respectively. The AUSROC of PSR for any varices at the threshold of 909 was 0.8867. The AUSROC of PSR for any varices in viral liver cirrhosis was 0.8675. The overall quality of studies was moderate. Significant heterogeneity and publication bias existed in the study. In conclusion, PSR can be used to identify varices in liver cirrhosis. PSR had a high sensitivity in viral liver cirrhosis.
منابع مشابه
Platelet count/spleen diameter ratio predicted the presence of esophageal varices in liver cirrhosis.
Thanks to Dr. Daniel J. Brotman of the Cleveland Clinic Foundation for pointing out an error in the confidence interval for sensitivity in “Platelet count/spleen diameter ratio predicted the presence of esophageal varices in liver cirrhosis” (1). The correct values appear in the Table. Operating characteristics of platelet count/spleen diameter ratio (cutpoint ≤ 909 for a positive diagnosis) fo...
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عنوان ژورنال:
دوره 2017 شماره
صفحات -
تاریخ انتشار 2017